Bacillus thuringiensis (Bt) is a unique bacterium in that it shares a common place with a number of chemical compounds which are used commercially to control insects important to agriculture and public health. Although other bacteria, including B. popilliae and B. sphaericus, are used as microbial insecticides, their spectrum of insecticidal activity is quite limited compared to Bt. Importantly, Bt is safe for humans and is the most widely used environmentally compatible biopesticide worldwide. Furthermore, insecticidal Bt genes have been incorporated into several major crops, rendering them insect resistant, and thus providing a model for genetic engineering in agriculture.

Bt toxins was found to be highly effective against certain crop pests, including the corn borer, corn rootworm, corn earworm, and bollwormsseveral . it has different strains of the bacterium are currently used to control for a number of agricultural insect pests and their larvae. Bt toxin can be applied to crops, including potatoes, corn, and cotton, as a spray or, less commonly, in granular form.

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